Gastroscopy with multiple biopsies shows that in severe chronic gastritis the mucosal pattern is distorted by irregular distribution of the gastric glands, increased numbers of mucus-secreting cells, and inflammatory infiltration of the stroma. The pattern of symptoms (pain-food-pain cycle) and failure to respond to antacids also distinguish chronic gastritis from the typical peptic ulcer. Ninety-two patients with chronic gastritis were treated with bed rest, sedatives, gastric suction, meals planned not to exceed the patient's critical volume, and a combination of aluminum hydroxide gel with oxethazaine hydrochloride, a topical anesthetic. While the severe forms of chronic gastritis were refractory to this treatment, the moderate and mild forms proved amenable, and the combination of antacid and anesthetic afforded relief from pain for periods up to six hours after each dose. Medication was continued for six days to 18 months without evidence of significant side-effects.
Deutsch E, Christian HJ. CHRONIC GASTRITIS: HISTOLOGICAL CRITERIA FOR MANAGEMENT AND MEDICAL TREATMENT WITH A MUCOSAL ANESTHETIC IN ALUMINUM HYDROXIDE. JAMA. 1959;169(17):2012–2015. doi:10.1001/jama.1959.03000340044012
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