Chlorphenoxamine was administered to 25 patients with paralysis agitans in a preliminary test to determine dosage and observe side-reactions. Thereafter it was administered to 136 patients who had been treated unsuccessfully with other drugs. It allayed tremor only in the occasional patient, and in some the tremor was accentuated. Its most consistent effect was on akinetic, tired, weak patients, who were enabled to move with greater celerity, strength, and endurance. It stimulated without inducing excitement and relaxed without causing flaccidity or enfeeblement. Three case histories illustrate its effects on the disabling symptoms of the patient. The side-effects observed were neither frequent nor serious. Tolerance did not seem to increase with lapse of time, and the favorable effects continued only as long as the drug was administered.
Doshay LJ, Constable K. TREATMENT OF PARALYSIS AGITANS WITH CHLORPHENOXAMINE HYDROCHLORIDE. JAMA. 1959;170(1):37–41. doi:10.1001/jama.1959.03010010039008
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