[Skip to Content]
[Skip to Content Landing]
Article
May 2, 1959

CIRCULATING BLOOD VOLUME CHANGES

Author Affiliations

3244 E. Douglas Wichita 8, Kan.

JAMA. 1959;170(1):108. doi:10.1001/jama.1959.03010010110020

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.

Abstract

To the Editor:—  We believe that the validity of blood volume determinations with use of radioiodinated serum albumin is well established provided proper precautions are taken to reduce technical error. In fact, Hlad and Tanz (J. Lab. & Clin. Med.52:289-298 [Aug.] 1958) reported a standard error of ±2% in vivo! That compensatory mechanisms are at work during anesthesia and operation is not questioned. Insofar as they do influence blood volume, it appears to be obvious that any blood volume determination, regardless of method, must reflect the changes they occur. Otherwise, the blood volume determinations would be without value.The statement that the use of tagged cells is the only correct method, simple and without technical error, we believe, is open to debate. Adherence of chromium to glass has been reported (Small and Verloop, J. Lab. & Clin. Med.47:255-260 [Feb.] 1956). Irregular mixing of radiochromate-labeled erythrocytes in

First Page Preview View Large
First page PDF preview
First page PDF preview
×