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To the Editor:—
We believe that the validity of blood volume determinations with use of radioiodinated serum albumin is well established provided proper precautions are taken to reduce technical error. In fact, Hlad and Tanz (J. Lab. & Clin. Med.52:289-298 [Aug.] 1958) reported a standard error of ±2% in vivo! That compensatory mechanisms are at work during anesthesia and operation is not questioned. Insofar as they do influence blood volume, it appears to be obvious that any blood volume determination, regardless of method, must reflect the changes they occur. Otherwise, the blood volume determinations would be without value.The statement that the use of tagged cells is the only correct method, simple and without technical error, we believe, is open to debate. Adherence of chromium to glass has been reported (Small and Verloop, J. Lab. & Clin. Med.47:255-260 [Feb.] 1956). Irregular mixing of radiochromate-labeled erythrocytes in
Powers WF. CIRCULATING BLOOD VOLUME CHANGES. JAMA. 1959;170(1):108. doi:10.1001/jama.1959.03010010110020
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