Both genetic and dietary factors are discernible in studies of the cause of coronary atherosclerosis. There are individual variations in the extent of development of supportive and contractile structures in the intima; in addition, certain effects of race, sex, and environment appear. Especially striking is the appearance of cholesterol deposits during the first year of life and their subsequent disappearance, alike in rabbits and in children, after weaning. The rate of infiltration decreases in childhood and is accelerated at adolescence in men and after the third decade in women. These considerations, with other results of recent investigations, indicate that the most important factors in coronary disease are nutritional and metabolic and that the greatest fault lies in the masculine love for rich food, alcohol, and tobacco.
Dock W. WHY ARE MEN'S CORONARY ARTERIES SO SCLEROTIC? JAMA. 1959;170(2):152–156. doi:10.1001/jama.1959.03010020010003
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