Reports received by a manufacturer from physicians using ristocetin, a new antibiotic, were collated with reports published in clinical literature, and the results were analyzed. Among the total of 333 cases in which the drug was used, there were 126 cases of pneumonia, and approximately 70% of these were caused by staphylococci. There were 46 cases of subacute bacterial endocarditis, and approximately 50% of these were caused by staphylococci. The drug was given either by intravenous injection or prolonged intravenous infusion. The most frequent side-effects were thrombophlebitis (20 cases, 6% of the total) and neutropenia (18 cases, 5.4%). Side-effects were absent in 258 (77.5%) of the patients. The side-effects were most frequent in patients receiving the larger doses, and on the basis of these findings it is recommended that the dosage of this antibiotic in adult patients should not normally exceed 2 Gm. per day. Approximately 60% of the patients were completely cured.
Herting RL, Lees B, Zimmermann AJ, Berryman GH. RISTOCETIN—A STATISTICAL REVIEW OF THREE HUNDRED THIRTY-THREE CASES. JAMA. 1959;170(2):176–178. doi:10.1001/jama.1959.03010020034010
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