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May 16, 1959


Author Affiliations

14 W. Young St. Somerville, N. J.

JAMA. 1959;170(3):361. doi:10.1001/jama.1959.03010030105029

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To the Editor:—  Many reports have appeared recently on the toxic manifestations of prochlorperazine (Compazine). It is a valuable tool in the symptomatic relief of vomiting in gastroenteritis and measles and in newborn infants. When it is used in appropriate dosage, based on weight, complications are rare. Few more alarming situations can occur than those which are seen in children with prochlorperazine toxicity. The signs, which have been well described elsewhere, include, briefly, an opisthotonic position, rolling up of the eyes, protrusion of the tongue, inability to speak or thick incoherent speech, and catatonic posturings.In our experience these complications are not related to dosage. We have seen them occur after as little as one rectal dose on each of two successive days and, on the other extreme, after the ingestion of a large number of spansules. We have also noted a lack of toxic manifestations in infants and very

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