The effectiveness of intradermally injected vaccine against Asian influenza was studied in an orphanage in Memphis, Tenn., with 168 children between the ages of 1 and 17 years. A single lot of monovalent Asian strain type A influenza vaccine containing 200 chick cell agglutination units per milliliter was used throughout the study. The outbreak of influenza in the orphanage began on the same day as in the city of Memphis. Four cases occurred before the first injection, 17 between the first and second, and 5 after the second. The outbreak in the orphanage had substantially ceased before the citywide epidemic had reached its peak. Comparison of the hemagglutination-inhibition titers of serum samples obtained before and after the injections, with a consideration of the time relation of the cases among the different age groups in the orphanage, indicated that the vaccine was effective when given intradermally.
Rendtorff RC, Walker LC, Rowland ME, Packer H. INTRADERMAL IMMUNIZATION AGAINST ASIAN INFLUENZA IN CHILDREN. JAMA. 1959;170(5):524–528. doi:10.1001/jama.1959.03010050018004
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