An outbreak of paralytic poliomyelitis occurred in southern Antioquia, Colombia, in January, 1958. A census located 2,922 families who agreed to participate in a program of vaccination, and the immune status of the population was ascertained by systematic blood sampling. Oral vaccination with attenuated strains of poliovirus (types 1, 2, and 3) began in May, 1958. Comparison of prevaccination and postvaccination serums showed that, of the vaccinated children who lacked demonstrable antibody at the time of vaccination, 91 % responded to type 1 virus, 72% to type 2, and 87% to type 3. Both the safety and the immunizing efficacy of the three strains of virus employed were convincingly demonstrated.
Abad-Gómez H, Piedrahita F, Solórzano R, da Silva MM. COMMUNITYWIDE VACCINATION PROGRAM WITH ATTENUATED POLIOVIRUS IN ANDES, COLOMBIA. JAMA. 1959;170(8):906–913. doi:10.1001/jama.1959.03010080014002
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