The anorexigenic effects of phenylpropanolamine and dextro amphetamine were compared in a study of 80 mentally deficient institutionalized patients, without dietary restrictions. One group received dextro amphetamine, two groups received phenylpropanolamine in dosages of 25 and 50 mg. thrice daily, and one group received a placebo. The average changes in weight for the four groups after two weeks were —4.6, —0.9, —0.8, and +0.3 lb. (—2.1, —0.41, —0.36, and +0.14 kg.) respectively. While the dextro amphetamine significantly reduced the voluntary intake of food in the first group, no significant effect was induced by the phenylpropanolamine even in double the recommended dosage.
Fazekas JF, Ehrmantraut WR, Campbell KD, Negron MC. COMPARATIVE EFFECTIVENESS OF PHENYLPROPANOLAMINE AND DEXTRO AMPHETAMINE ON WEIGHT REDUCTION. JAMA. 1959;170(9):1018–1021. doi:10.1001/jama.1959.03010090008002
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