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June 27, 1959


JAMA. 1959;170(9):1066-1068. doi:10.1001/jama.1959.63010090017011b

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Tuberculosis Vaccine (Tuberculosis Vaccine).— BCG vaccine.—Bacillus Calmette-Guérin vaccine.—  A freeze-dried preparation of the culture of an attenuated strain of bovine tubercle bacillus, Mycobacterium tuberculosis, originally isolated by Calmette and Guérin. It is standardized in accordance with requirements of the National Institutes of Health.

Actions and Uses.—  Tuberculosis vaccine, first licensed for general distribution in 1950, is proposed for use as an immunizing agent in the prevention of tuberculosis. Its use for this purpose is based on the ability of the vaccine to induce a positive tuberculin skin test reaction in a high percentage of individuals who are initially nonreactive to such a test. Conversion of negative tuberculin-tested subjects to positive reactors after vaccination is generally regarded as presumptive evidence of the development of immunity similar to that which follows a naturally resisted or healed primary sensitizing infection. Accordingly, tuberculosis vaccine is intended for, and should be used only in, individuals

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