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June 27, 1959


Author Affiliations

524 Cooper St. Camden 2, N. J.

JAMA. 1959;170(9):1108. doi:10.1001/jama.1959.03010090098024

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To the Editor:—  I read with interest the article, "Double-Blind Evaluation of Methylphenidate (Ritalin) Hydrochloride" by Darvill, in The Journal, April 11, page 1739, because I am conducting a study of this drug in outpatient psychiatric patients, as an adjuvant to psychotherapy. The patients take the drug only once weekly, just prior to the psychotherapeutic interview. To date, I have spent about eight months experimenting with the dosage and the effect of the drug on various patients at various times. I have recently begun a double-blind study.There are two important criticisms of the above article that I would make. Darvill makes no allowances for the wide variety of effect of this drug. In some of my patients the drug produced a very pleasant effect, as if they were on "cloud nine"; in an almost equal number it precipitated anxiety symptoms and caused a rebound depressive hangover. It would be

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