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July 4, 1959


Author Affiliations

Columbus, Ohio

From the Department of Medicine, Ohio State University College of Medicine.

JAMA. 1959;170(10):1178-1179. doi:10.1001/jama.1959.63010100004012b

Erythema nodosum is a reaction pattern of the skin characterized by the formation of symmetrical, nodular, erythematous, painful, and tender swellings on the pretibial surface of the legs. Less frequently, the lesions may appear on other parts of the body. The cause is not always determined but is usually a manifestation of an infection or drug eruption.1 Although erythema nodosum is not an uncommon manifestation of a deep fungal infection, such as coccidioidomycosis,2 to our knowledge there has been no reported association of this syndrome with histoplasmosis. The purpose of this report is to describe erythema nodosum occurring as a manifestation of histoplasmosis.

Report of a Case  An 18-year-old girl from Copenhagen, Denmark, was admitted to University Hospital on Jan. 7, 1958, with a "rash" on her legs of five days' duration. Ten days before admission she began to experience moderate intermittent headaches which required no therapy. Five