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Article
July 11, 1959

CORTICOSTEROID THERAPY IN RHEUMATOID ARTHRITIS: COMPARATIVE STUDY OF EFFECTS OF PREDNISONE AND PREDNISOLONE, METHYLPREDNISOLONE, TRIAMCINOLONE, AND DEXAMETHASONE

Author Affiliations

Louisville, Ky.

From the Arthritis Clinic and Department of Medicine, School of Medicine, University of Louisville.

JAMA. 1959;170(11):1253-1260. doi:10.1001/jama.1959.03010110001001
Abstract

Lack of documented comparative information has led to increasing confusion regarding relative merits of the various corticosteroid preparations in treatment of rheumatoid arthritis. Tested in a group of 65 patients with active rheumatoid arthritis were prednisone, prednisolone, methylprednisolone, triamcinolone, and dexamethasone. Comparable antirheumatic benefit was obtained with all compounds in the majority of patients. No one preparation demonstrated any consistently superior therapeutic advantage. Factors influencing choice of treatment include probable effectiveness, nature of unwanted side-effects, ease of administration, and cost to the patient.

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