Hydrochlorothiazide appears to be a potent diuretic as well as antihypertensive agent. Its main action is to produce sodium and chloride diuresis. Ten patients with essential hypertension and one with congestive heart failure were given 50 mg. of hydrochlorothiazide three times a day. The 10 experienced a fall in blood pressure, and the patient with edema had diuresis. The drug was well tolerated by all, and no major toxic effects were noted. Patients were discharged after one week of therapy in the hospital and examined weekly thereafter in the outpatient department. Perhaps the best way to regulate blood pressure in essential hypertension is to admit the patient to the hospital, place him on a no-sodium diet for several days, and then give a general diet along with a sodium diuretic agent.
Vertes V, Sopher M. CLINICAL STUDIES ON HYDROCHLOROTHIAZIDE— ANTIHYPERTENSIVE AND METABOLIC EFFECTS. JAMA. 1959;170(11):1271–1273. doi:10.1001/jama.1959.03010110019004
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