The two most recent tranquilizing derivatives of phenothiazine are trifluoperazine (Stelazine) and thioridazine (Mellaril). The former is the most potent phenothiazine compound available. Its side-effects, predominantly extrapyramidal in nature, may be adequately controlled in the hospital, but the drug is not recommended for office patients unless given in very small doses. Thioridazine has about one-tenth the potency, weight for weight, of trifluoperazine but, in equivalent doses, is free of significant side-effects, including Parkinsonism. It is recommended for use in both the hospital and office.
Kinross-Wright J. NEWER PHENOTHIAZINE DRUGS IN TREATMENT OF NERVOUS DISORDERS. JAMA. 1959;170(11):1283–1288. doi:10.1001/jama.1959.03010110031006
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