More thorough gross and microscopic study of pilonidal sinus specimens may reveal a higher incidence of carcinoma than has been indicated in the medical literature. Gross symptoms suggesting malignant change include bleeding, ulceration, and overgrowth. These are especially noteworthy when occurring in sinuses present for many years. Surgery consists of wide and deep excision. Carcinoma in a pilonidal sinus is most commonly of the squamous cell type, slow in growth and not prone to metastasize.
Weinstein M, Roberts M, Reynolds B. PILONIDAL SINUS CARCINOMA. JAMA. 1959;170(12):1394–1395. doi:10.1001/jama.1959.03010120030009
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