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July 18, 1959


Author Affiliations

Miami, Fla.

Clinical Instructor in General Practice, University of Miami School of Medicine.

JAMA. 1959;170(12):1410-1411. doi:10.1001/jama.1959.63010120002013a

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Colchicine is one of the oldest and most specific pharmaceuticals available. While newer agents such as the corticosteroids, phenylbutazone, and probenecid are valuable in the treatment of gouty arthritis, colchicine remains the most useful drug in the treatment of this disorder. Although colchicine is a remarkably safe drug, its oral administration frequently results in nausea, vomiting, and diarrhea. These manifestations act as a limiting factor and may obviate the full effectiveness of the drug. Colchicine injection is now available for intravenous administration. When the drug is given by this method, and the indicated dosage is not exceeded, gastrointestinal side-effects are rarely encountered and the response is more rapid than that obtained with the oral method. Cautious intravenous administration is also a valuable diagnostic procedure.

Report of Cases 

Case 1.—  An obese 43-year-old man developed pain and swelling of the left knee eight days after an automobile accident. There was no

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