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July 25, 1959


JAMA. 1959;170(13):1550-1551. doi:10.1001/jama.1959.63010130008013a

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Azuresin (Diagnex Blue).—  Azure A Carbacrylic Resin.—A complex of azure A and a polyacrylic carboxylic acid resin. Azure A is a blue dye which is chemically defined as 3-amino-7-dimethylaminophenazathionium chloride.

Actions and Uses.—  Azuresin, introduced in 1958, is employed as an indicator for the detection of gastric anacidity (achlorhydria) without intubation. After oral administration of the drug, the blue dye (azure A) in the resin is displaced by the hydrogen ions of free hydrochloric acid that may be present in the stomach. A part of the displaced azure A is absorbed and excreted in the urine within two hours after administration of the resin. A stimulant to gastric secretion is given one hour before administration of the resin. Urine voided during that hour serves as a control sample. The dye content of the urine specimen collected two hours after administration of the resin is visually estimated as an indication of

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