In 79 burned adults, including 11 with burns of over 50%, treated with saline solution alone, there was no two-day mortality. In 74 other adults, including 14 with burns of over 50%, treated with plasma plus dextrose and water, there was a 12% two-day mortality. Selection of patients was made on a strictly alternating basis. In 73 burned children treated with saline solution alone, there was a 19% two-day mortality. In 92 other children treated with a combination of plasma and saline solution, there was only a 9% mortality. Saline solution therapy is considered good emergency therapy for adults, and addition of plasma to saline solution reduced the over-all acute mortality in children, particularly in the more severely burned.
Markley K, Bocanegra M, Bazan A, et al. CLINICAL EVALUATION OF SALINE SOLUTION THERAPY IN BURN SHOCK: II. COMPARISON OF PLASMA THERAPY WITH SALINE SOLUTION THERAPY. JAMA. 1959;170(14):1633–1640. doi:10.1001/jama.1959.03010140013005
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