The Malmgren method for the isolation of cancer cells from whole blood was simplified by substituting a centrifuge process for the filtration method of collecting cells for examination. The new method, which can be carried out in the average laboratory, produces slides of a quality comparable to those from other techniques with regard to preservation of tumor cell structure, minimal cell clumping on the slide, and adequate red cell removal from the final preparation. The Papanicolaou preparation of the slide distinguishes the malignant cell when read by a competent cytologist.
Long L, Roberts S, McGrath R, McGrew E. SIMPLIFIED TECHNIQUE FOR SEPARATION OF CANCER CELLS FROM BLOOD. JAMA. 1959;170(15):1785–1788. doi:10.1001/jama.1959.03010150029008
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: