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August 8, 1959


Author Affiliations

1212 Seventh St. Santa Monica, Calif.

JAMA. 1959;170(15):1842. doi:10.1001/jama.1959.03010150086022

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To the Editor:—  Your guest editorial on spontaneous regression of malignant disease, in The Journal, April 11, page 1758, stated that the theory for spontaneous regression of malignant tumors had not been advanced. The theory for disappearance can be evolved from the research work of biochemists Dulkin and Lobstein of the Research Foundation for Diseases of the Eye. They found that lysozyme, an enzyme found in body fluids and in tears, in addition to being bacteriostatic, is carcinostatic for certain tumors in rats. The work, which resembles Fleming's experiments with penicillin in the manner of procedure, is promising. Clinical trials have not been made.Other body enzymes may also be carcinostatic. Experiments are planned to determine whether lens epithelium secretes carcinostatic substances. Cancer has not been reported in the lens. The progress of cancer is like that of other diseases—a struggle between host resistance and the virulence and degree of

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