In most patients treated earlier with chlorothiazide, maintenance of the previous status was obtained with a dose of hydrochlorothiazide one-tenth that of chlorothiazide. An important advantage appears to be absence of complaints of weakness during early weeks of treatment. Intravenous administration of hydrochlorothiazide is convenient and effective therapy. In oral therapy, daily administration is preferred because a more constant level of "compensation" is desirable. Hypertensive patients without clinical congestive failure showed improvement both symptomatically and by fall in blood pressure.
Schwartz G, Stechel GH, Fishman SI, Fankhauser A. CLINICAL THERAPEUTIC EVALUATION OF HYDROCHLOROTHIAZIDE (HYDRODIURIL). JAMA. 1959;170(17):2057–2060. doi:10.1001/jama.1959.03010170019004
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