Total protein-bound sialic acid content was determined in normal and pathological human serum with special reference to the C-reactive protein test. Almost all of the serum positive for C-reactive protein had high sialic acid levels. It is likely that different pathological processes may account for the appearance of C-reactive protein and increase in the serum sialic acid level. Nevertheless, it is believed that determination of the level of serum sialic acid should prove a useful adjunct to the diagnosis of rheumatic fever and related diseases. The C-reactive protein itself did not contain sialic acid.
Turumi K, Hamagami LT, Kenkel H. RELATIONSHIP OF SIALIC ACID AND C-REACTIVE PROTEIN LEVELS IN HUMAN SERUM. JAMA. 1959;170(18):2160–2162. doi:https://doi.org/10.1001/jama.1959.03010180012005
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