Significant among indications that we stand at the threshold of a new scientific era in radiotherapy are, first, evidence of a greater spirit of cooperation and mutual respect between surgeons and radiotherapists and, second, the availability of new sources of high-energy radiation and more precise methods of dosimetry. Fundamental laboratory studies now in progress in the field of cellular rediobiology may open the way to even more exciting practical results. Of special significance in this respect are new methods of cell culture, which should aid in the estimation of radiosensitivity of different classes of cells, and measures designed to eliminate differences in oxygenation in normal and neoplastic cells. It may be expected that radiation treatment will become still more rational and significantly wider in scope within the next decade or two.
Kaplan HS. NEW HORIZONS IN RADIOTHERAPY OF MALIGNANT DISEASE. JAMA. 1959;171(2):133–138. doi:10.1001/jama.1959.03010200001001
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