The usefulness of isoxsuprine hydrochloride as a dilator of peripheral blood vessels was studied in 46 patients with arteriosclerosis obliterans. Their ages ranged from 41 to 77 years, and gangrene was present in three. Objective evidence of improvement, in the form of increased walking distance, healing of gangrene, and oscillometric and plethysmographic data, was obtained in 39 patients. The isoxsuprine hydrochloride was given by mouth at dosages of 10 or 20 mg. three times a day for periods ranging from three weeks to 18 months. This dosage did not cause any untoward side-effects, and no contraindications were noted.
Samuels SS, Shaftel HE. USE OF A NEW VASODILATOR AGENT IN MANAGEMENT OF PERIPHERAL ARTERIAL INSUFFICIENCY. JAMA. 1959;171(2):142–145. doi:10.1001/jama.1959.03010200010003
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