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September 12, 1959


Author Affiliations

1401 Chestnut Ave. Long Beach 13, Calif.

JAMA. 1959;171(2):241. doi:10.1001/jama.1959.03010200109020

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To the Editor:—  In the clinical note "Erythema Nodosum as a Manifestation of Histoplasmosis" in The Journal, July 4, page 1178, the authors stated that "to our knowledge there has been no reported association of this syndrome with histoplasmosis." In order that the facts be correctly documented, I would like to call attention to an article by Heilbrunn and Cain, entitled "Mild Histoplasmosis Clinically Resembling Atypical Pneumonia and Accompanied by Erythema Nodosum and Arthritis" (J. Missouri M. A.47:503 [July] 1950). In this report a patient is described who was given a diagnosis of histoplasmosis, as a result of laboratory tests conducted by the United States Public Health Laboratory at the University of Kansas Medical Center. The patient is reported as having, among other findings, skin lesions described as "resembling erythema

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