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Article
September 19, 1959

"CASE REPORT" IN HUMAN PHARMACOLOGY: STUDY OF A SERIES OF PYRIMIDINEDIONE DIURETICS, INCLUDING AMINOMETRADINE (MICTINE) AND AMISOMETRADINE (ROLICTON)

Author Affiliations

New York

From the Department of Pharmacology, Cornell University Medical College, the Cardiovascular Research Unit, Beth Israel Hospital, and the Cardiac Service, Hospital for Joint Diseases. Dr. Greiner is now at the Baylor University College of Medicine, Houston, Texas. Dr. Ganz is a postdoctorate fellow, National Heart Institute (1954). Dr. Rao is a Fulbright fellow (1952) from Bangalore, India. Dr. Fujimori is a fellow, Institute of International Education (1953), from Tokoshima, Japan.

JAMA. 1959;171(3):290-295. doi:10.1001/jama.1959.03010210042012
Abstract

Greater interest is developing in the distinct scientific discipline identified as clinical pharmacology. Casual clinical trial of new therapeutic agents after screening of the material in laboratory animals too often has proved misleading. While the controlled clinical trial, with use of scientific pharmacology in human beings, is frequently used as a part of the more extensive definitive clinical evaluations, it is here proposed as a substitute for the casual clinical trial in the earliest stage of screening programs. The virtue of this method is that the results emerge out of an experimental design, that scientific evidence is secured expeditiously and with use of relatively few patients, and that the results are freer of chance and error.

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