Greater interest is developing in the distinct scientific discipline identified as clinical pharmacology. Casual clinical trial of new therapeutic agents after screening of the material in laboratory animals too often has proved misleading. While the controlled clinical trial, with use of scientific pharmacology in human beings, is frequently used as a part of the more extensive definitive clinical evaluations, it is here proposed as a substitute for the casual clinical trial in the earliest stage of screening programs. The virtue of this method is that the results emerge out of an experimental design, that scientific evidence is secured expeditiously and with use of relatively few patients, and that the results are freer of chance and error.
Greiner T, Gold H, Ganz A, et al. "CASE REPORT" IN HUMAN PHARMACOLOGY: STUDY OF A SERIES OF PYRIMIDINEDIONE DIURETICS, INCLUDING AMINOMETRADINE (MICTINE) AND AMISOMETRADINE (ROLICTON). JAMA. 1959;171(3):290–295. doi:10.1001/jama.1959.03010210042012
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