Hypsarhythmia is a type of epilepsy which has, in the past, had an extremely poor prognosis. Eleven per cent of the patients died before the third year of life, and 87% of those who lived were feeble-minded. The present series of 60 children were treated with corticotropin for one year, with marked improvement in 36 and almost complete relief in 5 as judged by electroencephalographic criteria and subjective symptoms. The mode of action of the drug was not explained, and its effectiveness in the individual case could not be predicted from a knowledge of the etiology. By contrast with the poor results obtained in the past, these recent results with corticotropin are encouraging.
Stamps FW, Gibbs EL, Rosenthal IM, Gibbs FA. TREATMENT OF HYPSARHYTHMIA WITH ACTH. JAMA. 1959;171(4):408–411. doi:10.1001/jama.1959.03010220032009
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