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Article
October 3, 1959

EXPERIENCE WITH HALOTHANE (FLUOTHANE) IN MORE THAN FIVE THOUSAND CASES

Author Affiliations

Burlington, Vt.

From University of Vermont, College of Medicine.

JAMA. 1959;171(5):535-540. doi:10.1001/jama.1959.03010230033008
Abstract

As a result of this extensive experience with a series of entirely unselected cases, it is concluded that halothane is a safe and predictable anesthetic when it is administered with equipment which permits accurate control of the vapor concentration and when concentrations are never allowed to exceed 2%. Special equipment and techniques believed necessary will be described in a subsequent paper. With such control, severe hypotension has ceased to be a problem, and there has been no evidence of hepatic, renal, or undue myocardial toxicity. Addition of a muscle relaxant was rarely necessary. There was remarkable absence of salivary and bronchial secretions. Further studies are being conducted to clarify the supposed dangers of using halothane in closed circuit.

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