As a result of this extensive experience with a series of entirely unselected cases, it is concluded that halothane is a safe and predictable anesthetic when it is administered with equipment which permits accurate control of the vapor concentration and when concentrations are never allowed to exceed 2%. Special equipment and techniques believed necessary will be described in a subsequent paper. With such control, severe hypotension has ceased to be a problem, and there has been no evidence of hepatic, renal, or undue myocardial toxicity. Addition of a muscle relaxant was rarely necessary. There was remarkable absence of salivary and bronchial secretions. Further studies are being conducted to clarify the supposed dangers of using halothane in closed circuit.
Abajian J, Brazell EH, Dente GA, Mills EL. EXPERIENCE WITH HALOTHANE (FLUOTHANE) IN MORE THAN FIVE THOUSAND CASES. JAMA. 1959;171(5):535–540. doi:https://doi.org/10.1001/jama.1959.03010230033008
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