Diffuse enlargement of the thyroid gland, low protein-bound iodine value, and the appearance of a nodule in one lobe of the thyroid in an 11-year-old girl led to the diagnosis of thyroid disease with the possibility of carcinoma. At operation the entire gland was found to be diffusely enlarged to about three times normal size. Enough tissue was removed for microscopic study to reveal striking alterations of the follicular architecture. The pathological diagnosis was acute and chronic nonspecific thyroiditis. Records of only 31 comparable cases have been found in a search of the literature. The patient was treated postoperatively with thyroid extract. Six months after operation the patient was receiving a maintenance dosage of 64 mg. of thyroid extract per day; she appeared clinically euthyroid, and the protein-bound iodine value was normal.
Brown H, McGarity WC. CHRONIC THYROIDITIS IN CHILDHOOD. JAMA. 1959;171(9):1182–1186. doi:10.1001/jama.1959.03010270018005
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