A 22-year-old man was hospitalized with complaints of dyspnea and hemoptysis and a history of heart disease and coagulation defects. Repeated study of the clotting mechanism showed the outstanding deficits to be those of thromboplastin generation characteristic of hemophilia B. When the patient's cardiac failure and hepatic dysfunction were relieved, the coagulation defect also disappeared. The hemophilia in this case, therefore, was not hereditary but acquired.
Gollub S, Bolton H, Hessert E, Ulin A. ACQUIRED HEMOPHILIA B: REPORT OF CASE WITH DIAGNOSTIC LABORATORY FINDINGS. JAMA. 1959;171(10):1333–1336. doi:https://doi.org/10.1001/jama.1959.03010280057014
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