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November 7, 1959

The Barbiturate Withdrawal Syndrome: A Clinical and Electroencephalographic Study

JAMA. 1959;171(10):1436-1437. doi:10.1001/jama.1959.03010280160039

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


This monograph, the first of its kind, presents useful information for both the clinician and the researcher. The subject matter should appeal to a wide cross section of specialists in both fields. The author deserves credit for collating data on 78 chronically addicted barbiturate users as well as 40 patients who are used for comparison and control. The study represents more than five years of research.

The historical and introductory data are well presented in text and tables without being too lengthy. Throughout the monograph liberal use is made of clearly presented figures and tables. Methods are well described, and the use of controls is notable throughout. The monograph is comprehensive in that clinical, pharmacological, chemical, neuropathological, and electroencephalographic data are included. The idea is presented that the barbiturates which disappear slowly from the blood are less likely to induce major abstinence manifestations on abrupt withdrawal. The use of photic

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