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November 14, 1959


Author Affiliations

Hospital of the University of Pennsylvania Philadelphia 4.

JAMA. 1959;171(11):1602. doi:10.1001/jama.1959.03010290160028

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To the Editor:—  Dr. Sterne's article "Exchange Transfusion for Aspirin Poisoning" in The Journal, Aug. 15, page 1924, requires comment. We agree with the author that aspirin poisoning is a real danger in infancy and that exchange transfusion has a place in therapy, but we cannot agree with the management of the presented case. It is stated that the child received 0.75 Gm. of aspirin in the preceding 48-hour period. Assuming that the child weighed 10 lb. (4,536 Gm.), which seems reasonable in light of the 100-cc. blood transfusion and stated age of 6 weeks, this does not represent a toxic dose when given over a two-day period. Nelson's "Textbook of Pediatrics" states that a dose of about 150 mg. per kilogram given over a short period of time represents a toxic dose. Further proof that the level in all probability was not toxic is the statement that the blood

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