The clinical value of a specific technique of exercise was investigated in 47 adults with unilateral injuries to the knee. The patient, in the sitting position, used the quadriceps femoris to extend the knee against a maximum weight load and to maintain full extension for five seconds. This was done once daily. The load was increased by 1.25 lb. (0.63 kg.) each day. The strength of the uninvolved leg was determined not oftener than once weekly. Three case histories illustrate the sequence of events. Under these conditions the prescribed exercise produced a steady increase in strength of the ipsilateral muscle up to a maximum, with corresponing resolution of clinical symptoms; no crossing of strength effect between the ipsilateral and contralateral muscles was observed.
Rose DL. BRIEF MAXIMAL ISOTONIC EXERCISES IN THE TREATMENT OF KNEE INJURIES. JAMA. 1959;171(12):1673–1675. doi:10.1001/jama.1959.03010300047012
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