Exploratory thoracotomy was performed in order to determine the exact nature of the lesion in 85 patients whose chest roentgenograms had revealed solitary nodules in the peripheral parts of the lungs. The study was limited to patients who had no pulmonary symptoms and whose roentgenograms showed a generally rounded shadow, confined to the lung parenchyma, with either minimal calcification or none at all. Sixty-two of the lesions were in patients under 60 years of age, and 24 (39%) of these were malignant. Twenty-three were in patients over 60, and 13 (57%) of these were malignant. While 42 of the lesions were non neoplastic, 43 were neoplastic and 30 of these were primary carcinomas. When such shadows are seen in chest roentgenograms, early thoracotomy is recommended in order to determine whether the lesion is malignant or benign.
Greer AE, Carey JM, Zuhdi N. EXPEDITIOUS EVALUATION OF CIRCUMSCRIBED PULMONARY SHADOWS. JAMA. 1959;171(13):1783–1786. doi:https://doi.org/10.1001/jama.1959.03010310015004
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