Demonstration of multiple epiphrenal diverticula in a male parent and two of his children, with tracheoesophageal fistula found at birth in a grandchild, lends strong support to the concept that familial genetic defect is a possible etiological factor. The diverticula in these reported cases were found to extend over the entire lower esophageal segment. Acute complications had not been recorded in the parent or children. Evidence indicates that such patients should be treated conservatively.
Hird WE, Hortenstine CB. FAMILIAL ESOPHAGEAL EPIPHRENAL DIVERTICULA. JAMA. 1959;171(14):1924–1927. doi:10.1001/jama.1959.03010320014004
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