Radioiodine (I131) has been used in the treatment of thyroid cancer metastases since 1943. The harmful radiation effects of this agent on the blood-forming organs are well recognized, but other body structures are seldom injured. Reports of permanent damage to the reproductive organs by I131 are exceedingly rare. The case we are reporting seems to represent a clear instance of injury to the testes from radioiodine administered as treatment for metastatic thyroid carcinoma.
Report of a Case
A 24-year-old man was found during the course of a routine x-ray examination of the chest in March, 1952, to have widespread diffuse nodular densities in both lung fields (fig. 1). He felt entirely well at this time, had lost no weight, and had no respiratory symptoms whatever. It was known that a roentgenogram of the chest in 1949 had shown no abnormalities. Physical examination was entirely negative except for a
Kammer H, Goodman MJ. STERILITY AFTER RADIOIODINE THERAPY FOR METASTATIC THYROID CARCINOMA. JAMA. 1959;171(14):1963–1965. doi:10.1001/jama.1959.73010320001013
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