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Article
December 12, 1959

MYOPATHY AND HYPERCALCEMIA OCCURRING WITH CARCINOMA OF THE KIDNEY

Author Affiliations

Durham, N. C.

From the Urologie and Medical Services, Durham Veterans Administration Hospital, and the departments of urology and medicine, Duke University School of Medicine. Dr. Alanis is now Assistant Professor of Urology, Escuela de Medicina de la Universidad de Nuevo Leon, Monterrey N. L., Mexico.

JAMA. 1959;171(15):2076-2080. doi:10.1001/jama.1959.03010330038010
Abstract

In this case of a 63-year-old man the essential complaint during the first three months of illness was muscular weakness, affecting especially the legs and progressing to complete disability. Later symptoms led to surgical removal of the right kidney and diagnosis of clear-cell carcinoma. The nephrectomy was followed by improvement in neuromuscular status until muscle strength had returned to almost normal. Deep reflexes in the legs did not return, and biopsy of the quadriceps femoris muscle revealed extensive atrophy. Hypercalcemia was detected before operation and subsided thereafter; its time-relation to other blood-chemical findings, to the neuromuscular disturbance, to osteoblastic activity manifested in the bones, and to the ultimate appearance of masses in both lungs suggests that calcium played a central role in the symptomatology of this patient.

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