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December 19, 1959


Author Affiliations

Palo Alto Medical Clinic Palo Alto, Calif.

JAMA. 1959;171(16):2246. doi:10.1001/jama.1959.03010340090024

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To the Editor:—  I think it would be wise to exercise caution regarding the conclusions of Koegler and Colbert in their article on childhood schizophrenia in The Journal, Oct. 24, page 1045. Many other experts do not accept a primarily physiological basis for childhood schizophrenia, and, to date, there are no incontrovertible biochemical or physiological findings in adult or childhood schizophrenia.One of the most recent biochemical studies (Mann and LaBrosse: A. M. A. Arch. Gen. Psychiat.1:547 [Nov.] 1959) reported no difference in findings between childhood and adult schizophrenics and controls. Kanner, who originated the term "childhood autism," found no evidence for genetic factors in these children, and Szurek and his collaborators, after 10 years of intensive research, concluded that childhood schizophrenia has a psychological etiology.References to the reticular formation or the limbic system have become de rigueur in physiologically oriented articles on behavior. Such speculations do

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