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December 19, 1959

Ciba Foundation Symposium on the Regulation of Cell Metabolism

JAMA. 1959;171(16):2275. doi:10.1001/jama.1959.03010340119031

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To biochemists the basic systems controlling cellular metabolism are to be found within the cell itself; such factors as hormones and the nervous system are thought to superimpose their action on these basic systems. This symposium is a discussion by experts for experts—as the preface points out— of nonhormonal regulations of cellular chemistry. The theme is well stated at the outset by the symposium chairman, Sir Hans Krebs. He says: "It is probable that regulation of metabolism operates always through variations of reaction velocities.... One of the main problems in the analysis of regulation is the identification of those component reactions which are rate-limiting." This leads into brilliant and authoritative presentations of such subjects as the control of rate of intracellular respiration, quantitative aspects of the control of oxygen utilization, control of oxidative phosphorylation, choice of oxidative pathways of carbohydrate metabolism, alternative pathways of electron transport, limiting factors in glycolysis,

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