We1 studied the influence of prophylactic, concomitantly given doses of antibiotics on the incidence of staphylococcic infection in patients treated with steroids on the dermatological wards of Bellevue Hospital. True, steroid therapy alone is not without hazard in this respect,2 but, as will be seen from our study, the prophylactic addition of antibiotics certainly does not always succeed in preventing infection and may, in some cases, convert a potential hazard into reality.
Subjects and Procedures
We studied all admissions to the dermatological service of Bellevue Hospital over a nine-month interval (July 1, 1958, through March 31, 1959). From all admissions, we divided the patients into the following treatment groups: (1) patients receiving neither steroids nor antibiotics, (2) patients receiving antibiotics only for specific infectious processes, (3) patients receiving steroids only, (4) patients receiving steroids and concomitant prophylactic doses of antibiotics, and (5) all patients admitted (groups 1-4).The
Gibbs RC, Biro L, Sulzberger MB. PROPHYLACTIC ADMINISTRATION OF ANTIBIOTICS IN PATIENTS RECEIVING STEROIDS SYSTEMICALLY. JAMA. 1960;172(1):11–12. doi:10.1001/jama.1960.03020010068004
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