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To the Editor:—
Differing points of view about the treatment of common disease syndromes are all too frequent in medical practice. These differences are well illustrated in the first two articles in The Journal, Nov. 21, 1959. The first paper is entitled, "Contemporary Therapy of the Menopausal Syndrome," by Kupperman and co-workers, and the second, "Prolonged Estrogen Therapy in Postmenopausal Women," by Wallach and Henneman. Kupperman and associates report superior results with combined estrogen-androgen therapy, whereas Wallach and Henneman found no advantage in such a combination in the long-term treatment of patients with osteoporosis. The latter workers reported an incidence of complications of only 5% in patients taking prolonged estrogen therapy.In my experience, and that of many other chinicians, estrogen administered in the dosage range used by Wallach and Henneman is followed more frequently by complications. These side-reactions can be prevented by therapy of the menopausal syndrome and postmenopausal
Glass SJ. COMBINED ESTROGEN-ANDROGEN THERAPY. JAMA. 1960;172(6):599. doi:10.1001/jama.1960.03020060089027
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