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To the Editor:—
I would like to comment on the question submitted by Dr. Jabush on the association of carpal tunnel syndrome to systemic disease, appearing in Questions and Answers in The Journal, Nov. 14, 1959. I disagree with the answer that systemic disease is not found in patients exhibiting this syndrome. In a personally studied case (with Dr. William Dameshek), the syndrome appeared in a patient who had had multiple myeloma for about two and one-half years. The median nerve compression was relieved neurosurgically. At the time of the operation material removed from the patient's wrist was found to be "amyloid." While I do not have the exact reference to this association, I do recall an abstract which appeared in Modern Medicine, probably in 1957, in which several patients with amyloidosis, both primary and secondary, in whom carpal tunnel syndrome was present, were described.
Rubio F. CARPAL TUNNEL SYNDROME. JAMA. 1960;172(7):733. doi:https://doi.org/10.1001/jama.1960.03020070091032
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