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July 7, 1962

Correlation of Blood and Fecal Radioactivity: After Oral Administration of I131-Labeled Triolein

Author Affiliations

Temple, Tex.
From the Departments of Internal Medicine and Clinical Research, Scott and White Clinic.

JAMA. 1962;181(1):35-37. doi:10.1001/jama.1962.03050270037007

THE ORAL administration of radioactive iodine (I131)-labeled triolein is used widely now as a test of fat absorption. It has been advocated as a screening procedure for the detection of steatorrhea in all patients suspected of malabsorption of fat due either to disease of the small bowel or to insufficiency of pancreatic exocrine secretion. The test has the advantage that when blood radioactivity alone is measured as an indication of fat absorption, the results are available in 6 to 8 hours. When fecal radioactivity is used as a test of fat absorption, the determination is more simple than chemical analysis for fat.

However, we have observed that the results of blood and fecal radioactivity determinations during the same test are not always in agreement as to the presence or absence of fat malabsorption.

The purpose of the present study was to determine what limiting values for these 2