This controlled, double-blind clinical trial was designed to compare the effectiveness of meperidine alone and meperidine combined with either promethazine or propiomazine in obstetrical analgesia. A statistical method for randomization was used to divide 520 women in labor into 3 treatment groups. Neither the patient nor the examining physician knew which of the 3 drug combinations was being given. It was found that the use of either promethazine or propiomazine in conjunction with meperidine contributed to a calmer, more comfortable labor and a more easily managed patient. No statistically significant difference was found, however, between the effects of these 2 tranquilizers. There was no evidence that either compound potentiated the analgesic effect of meperidine.
Powe CE, Kiem IM, Fromhagen C, Cavanagh D. Propiomazine Hydrochloride in Obstetrical Analgesia: A Controlled Study of 520 Patients. JAMA. 1962;181(4):290–294. doi:10.1001/jama.1962.03050300010002
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