During the past 5 years, 5-fluorouracil (5-FU) was used to treat 1,091 patients with from 1 to 54 courses. An attempt was made to treat each patient to slight toxicity with each course of therapy given at monthly intervals except poor-risk patients who either were not treated or given a poor-risk schedule. Of 428 patients with measurable lesions treated with 5-FU, 91 met all our criteria of improvement for an average duration of 9 months before reactivation of the disease occurred. The lesions found most responsive to the drug were cancer of the breast, colon or rectum, stomach, cervix, ovary, and malignant hepatoma. Squamous-cell carcinoma of the head and neck, carcinoma of the lung, hypernephroma, and malignant melanoma were unresponsive.
Ansfield FJ, Schroeder JM, Curreri AR. Five Years Clinical Experience with 5-Fluorouracil. JAMA. 1962;181(4):295–299. doi:10.1001/jama.1962.03050300015003
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