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August 4, 1962

Massive Ovarian Hyperstimulation with Clomiphene Citrate

Author Affiliations

New York City

JAMA. 1962;181(5):443-445. doi:10.1001/jama.1962.03050310083018b

CLOMIPHENE CITRATE (l-[p-(B-diethylaminoethoxy) phenyl]-l,2-diphenyl-2-chloroethylene), which is a nonproprietary name for the code name MRL/41, is an analogue of the synthetic, nonsteroid estrogen, chlorotrianisene. This compound is of interest because its administration to women with a wide variety of nonovulatory menstrual abnormalities frequently results in apparent ovulation.

It is the purpose of this report to present a case of massive bilateral ovarian enlargement, multiple corpora lutea, ascites, and hydrothorax in association with the administration of MRL/41.

Report of a Case

The patient, an 18-year-old unmarried female, was first seen in February, 1961. Menarche occurred at Age 11, but menses were always scant and occurred at 2- to 7-month intervals. She was 63 in. tall and weighed 95 lb. (43.0 kg.). Hair distribution was normal except for a male-type pubic escutcheon. The breasts were small with well developed glandular tissue. External genitalia were normal except for a slightly enlarged clitoris. Rectal examination