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August 18, 1962

The Long-Term Follow-Up of Malignant Hypertension

Author Affiliations

Submitted in honor of Chester S. Keefer, M.D., and the Golden Anniversary of the Evans Memorial Department of Clinical Research.; From the School of Medicine, Boston University, and the Massachusetts Memorial Hospitals.

JAMA. 1962;181(7):571-576. doi:10.1001/jama.1962.03050330001001

In a 25-year study of 251 patients with malignant hypertension, the survival rate of 160 patients who were treated by the lumbodorsal splanchnicectomy was approximately the same as that of the patients, treated with the newer antihypertensive drugs for the first 4 years of observaion. Thereafter, the survival rate of medically treated patients, reported recently in several selected studies, dropped noticeably and was less at the end of 5 years than the survival rate of the surgically treated patients at the end of 10 years. Although the use of antihypertensive drugs has prolonged the survival of malignant hypertensive patients, studies will have to be extended over a longer period of time before valid comparisons can be made between the results of drug therapy and the results of surgical treatment.