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August 18, 1962

Thesaurosis Versus Sarcoidosis: A Preliminary Note

Author Affiliations

Wilmington, Del.

JAMA. 1962;181(7):635-637. doi:10.1001/jama.1962.03050330065019a

DURING THE COURSE of a recent survey of the pathogenesis of Boeck's disease, inquiry was directed to inhaled environmental agents as a possible explanation for modifications of the chemical constitution of the lung attendant on pulmonary sarcoidosis. An analysis of the mineral content of the lung of 30 cases of sarcoidosis had brought to light the excessive presence of certain elements and a deficiency of others(table).

Among the pulmonary granulomata which have been attributed to inhaled substances, those which have recently been described as representative of the new entity, thesaurosis, decisive morphologic resemblance to sarcoidotic lesions may be recognized. Thesaurosis has been ascribed to the pulmonary and lymph node deposition of polyvinyl pyrrolidone and possibly even carboxymethylcellulose, dextran, or polyvinyl alcohol inhaled under Chemical Profile in Pulmonary Sarcoidosis, Spectrographic Analysis of Lung Ash (Average for 30 Cases) conditions of excessive exposure to certain brands of hair spray. The similarity between