The study determined, in an ambulatory population comprising 963 females and 549 males over 25 years of age, the relationship between smoking habits and serologic abnormalities as measured by the presence of C-reactive protein—CRP —and an abnormal seroflocculant for ethyl choledienate—SF. When the effect of age was held constant, the correlation between the incidence of positive SF and CRP tests and increased cigarette consumption was significant in both male and female groups. When the effect of age was not held constant, a significant difference was observed between the frequency of positive SF tests among males who did not smoke and those who smoked cigarettes regardless of the number smoked. The only significant difference in frequency of positive CRP tests in males was observed between nonsmokers and those smoking more than one pack of cigarettes per day.
Heiskell CL, Miller JN, Aldrich HJ, Carpenter CM. Smoking and Serologic Abnormalities. JAMA. 1962;181(8):674–677. doi:10.1001/jama.1962.03050340012003
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